Research
| Title： | Effect of Dietary Lactobacillus plantarum Supplementation on the Growth Performance, Intestinal Health, Antioxidant Capacity, and mTOR Signaling Pathway of Juvenile Coho Salmon (Oncorhynchus kisutch) |
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| First author： | Zhang, Qin; Li, Lan; Qin, Rongxin; Meng, Liuqing; Liu, Dongsheng; Tong, Tong; Xu, Lixiao; Liu, Yongqiang; Kong, Weiguang |
| Journal： | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| Years： | 2025 |
| DOI： | 10.3390/ijms26030907 |
| Abstract： | This study investigates the effect of dietary Lactobacillus plantarum supplementation on juvenile coho salmon (Oncorhynchus kisutch). Four groups of the juveniles (initial weight 103.87 +/- 2.65 g) were fed for 10 weeks with four diets containing 0 (control diet), 10(5) (T1), 10(7) (T2), and 10(9) (T3) cfu/g of L. plantarum. The main results are as follows: Compared with the control diet, the final weight, specific growth rate (SGR), and weight gain rate (WGR) of the juveniles fed the T1, T2, and T3 diet significantly (p < 0.05) increased, while the feed coefficient ratio (FCR) expressed an opposite trend. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) in the serum of the juveniles fed the T2 diet significantly (p < 0.05) increased, while the malondialdehyde (MDA) expressed an opposite trend. The expression of phosphatidylinositol 4,5-bisphosphate 3-kinase (pi3k), AKT-interacting protein (akt), mechanistic target of rapamycin kinase (mtor), glucose-6-phosphate dehydrogenase (g6pd), sod, cat, and gsh-px genes in the liver of the juveniles fed the T2 diet significantly (p < 0.05) increased. In conclusion, the T2 diet significantly improved the growth performance, antioxidant capacity, and upregulated key mTOR pathway genes in juvenile coho salmon. |
