Research
| Title： | Starvation Causes Energy Metabolism Alterations with The Stress and Immune Response Enhancement in Parabotia fasciata |
|---|---|
| First author： | Zhang, Futie; Hu, Xigeng; Cui, Yunwen; Wang, Tao |
| Journal： | TURKISH JOURNAL OF FISHERIES AND AQUATIC SCIENCES |
| Years： | 2025 |
| DOI： | 10.4194/TRJFAS26567 |
| Abstract： | Fish often face starvation stress in the natural environment. Parabotia fasciata is widely distributed in China and very promising to become a new type of farmed fish.To understand the response mechanism of P. fasciata to starvation stress and to develop an economical and scientific feeding strategy, transcriptomic analysis was conducted in P. fasciata intestine in three experimental groups: satiated, semi-satiated and hungry. In the case of starvation, this fish reduced its metabolic levels. Immune and stress responses of P. fasciata were enhanced. And genes related to ubiquitination modification pathway, autophagy and lysosomal degradation pathway were also significantly upregulated. However, under starvation conditions, genes related to normally functional protein (amino acid) and fatty acid metabolism were down-regulated, genes related to glycogen synthesis pathway increased rapidly (glycogen synthase), while gluconeogenesis levels were slightly down-regulated, but genes related to glycogen hydrolysis and the glycolysis pathway were bidirectionally functioned. It suggests that protein and carbohydrate, instead of the fatty acid, maybe be the first choice of P. fasciata energy source in the case of starvation. This study provided valuable information for the metabolism and immune response in P. fasciata intestine under starvation conditions. |
