Research
| Title： | Zebrafish hif1β attenuates antiviral innate immunity by suppressing Irf7 transcriptional activity |
|---|---|
| First author： | Yuan, Le; Ouyang, Gang; Liao, Qian; Song, Yanan; Wang, Yanyi; Li, Ziyi; Li, Zhi; Li, Jun; Wang, Jing; Xiao, Wuhan |
| Journal： | JOURNAL OF IMMUNOLOGY |
| Years： | 2025 |
| DOI： | 10.1093/jimmun/vkaf018 |
| Abstract： | HIF1 beta, which serves as a common binding partner of the aryl hydrocarbon receptor and hypoxia-inducible factor (HIF)-alpha subunits, plays a key role in 2 cellular signaling pathways: the aryl hydrocarbon receptor and HIF pathways. Whether HIF1 beta is involved in antiviral innate immunity remains to be determined. In this study, we show that zebrafish hif1 beta is induced by viral infection. Overexpression of hif1 beta attenuates cellular antiviral responses. Further mechanistic assays indicate that zebrafish hif1 beta interacts with irf7 to repress irf7 transcriptional activity. Disruption of hif1 beta in zebrafish promotes survival following challenge with spring viremia of carp virus. Consistently, antiviral-responsive genes are significantly increased and spring viremia of carp virus replication is reduced in hif1 beta-null zebrafish. Thus, we uncover an expected role for hif1 beta in response to viral infection. |
