Research
| Title： | Identification and establishment of type IV interferon and the characterization of interferon-upsilon including its class II cytokine receptors IFN-upsilon R1 and IL-10R2 |
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| First author： | Chen, Shan Nan; Gan, Zhen; Hou, Jing; Yang, Yue Cong; Huang, Lin; Huang, Bei; Wang, Su; Nie, Pin |
| Journal： | NATURE COMMUNICATIONS |
| Years： | 2022 |
| DOI： | 10.1038/s41467-022-28645-6 |
| Abstract： | Interferons are critical soluble components of the inflammatory process and are composed of three types with associated receptor complexes. Here the authors identify and characterise the type IV interferon, IFN-upsilon, and identify its associated receptors, denote functionality during in vivo infection and ascertain its genomic localisation. Interferons (IFNs) are critical soluble factors in the immune system and are composed of three types, (I, II and III) that utilize different receptor complexes IFN-alpha R1/IFN-alpha R2, IFN-gamma R1/IFN-gamma R2, and IFN-lambda R1/IL-10R2, respectively. Here we identify IFN-upsilon from the genomic sequences of vertebrates. The members of class II cytokine receptors, IFN-upsilon R1 and IL-10R2, are identified as the receptor complex of IFN-upsilon, and are associated with IFN-upsilon stimulated gene expression and antiviral activity in zebrafish (Danio rerio) and African clawed frog (Xenopus laevis). IFN-upsilon and IFN-upsilon R1 are separately located at unique and highly conserved loci, being distinct from all other three-type IFNs. IFN-upsilon and IFN-upsilon R1 are phylogenetically clustered with class II cytokines and class II cytokine receptors, respectively. Therefore, the finding of this IFN ligand-receptor system may be considered as a type IV IFN, in addition to the currently recognized three types of IFNs in vertebrates. |
