Research
| Title： | Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses |
|---|---|
| First author： | Feng, Hui; Zhang, Yi-Bing; Gui, Jian-Fang; Lemon, Stanley M.; Yamane, Daisuke |
| Journal： | PLOS PATHOGENS |
| Years： | 2021 |
| DOI： | 10.1371/journal.ppat.1009220 |
| Abstract： | The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader view, linking IRF1 to a wide range of functions in protection against invading pathogens. Conserved throughout vertebrate evolution, IRF1 has been shown in recent years to mediate constitutive as well as inducible host defenses against a variety of viruses. Fine-tuning of these ancient IRF1-mediated host defenses, and countering strategies by pathogens to disarm IRF1, play crucial roles in pathogenesis and determining the outcome of infection. |
