Research
| Title： | In vitro synergistic effects of fisetin and norfloxacin against aquatic isolates of Serratia marcescens |
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| First author： | Dong, Jing; Ruan, Jing; Xu, Ning; Yang, Yibin; Ai, Xiaohui |
| Journal： | FEMS MICROBIOLOGY LETTERS |
| Years： | 2016 |
| DOI： | 10.1093/femsle/fnv220 |
| Abstract： | Serratia marcescens is a common pathogenic bacterium that can cause infections in both humans and animals. It can cause a range of diseases, from slight wound infections to life-threatening bacteraemia and pneumonia. The emergence of antimicrobial resistance has limited the treatment of the diseases caused by the bacterium to a great extent. Consequently, there is an urgent need to develop novel antimicrobial strategies against this pathogen. Synergistic strategy is a new approach to treat the infections caused by drug-resistant bacteria. In this paper, we isolated and identified the first multi-resistant pathogenic Serratia marcescens strain from diseased soft-shelled turtles (Pelodiscus sinensis) in China. We then performed a checkerboard assay; the results showed that out of 10 tested natural products fisetin had synergistic effects against S. marcescens when combined with norfloxacin. The time-kill curve assay further confirmed the results of the checkerboard assay. We found that this novel synergistic effect could significantly reduce the dosage of norfloxacin against S. marcescens. |
